A single active ingredient that prevents hair loss and hair greying and effectively promotes hair growth and regeneration – we all want it!

Understanding Hair Regeneration

First, we need to be introduced to the key players of hair growth and regeneration:

• Wnt/β-Catenin signaling pathway
• DKK1
• RSPO1

The Wnt/β-Catenin signaling pathway is crucial for hair follicle stem cell activation, hair regeneration, and overall hair follicle development. It plays a key role in the anagen phase (growth phase) of the hair cycle and is a primary target for potential hair growth therapies. 

However, DKK1 can directly inhibit the Wnt/β-catenin signaling pathway. This inhibition can lead to a delay in the transition from the telogen (resting) phase to the anagen (growth) phase, contributing to hair loss. 

RSPO1 is a protein that plays a significant role in hair growth by activating the Wnt/β-catenin signaling pathway and antagonizing the effects of DKK1. Therefore, RSPO1 has a crucial dual function: 1) It activates the Wnt/β-Catenin signaling pathway, and 2) inhibits DKK1 activity to promote hair growth and treat hair loss and greying hair.

Recombinant RSPO1 protein is now being sold and used to treat androgenetic alopecia (AGA) and female pattern baldness. It costs around $598 for 0.5 µg and $4,400 for 0.5mg. It means that it will cost one an arm and a leg to be able to have active hair growth and solve the devastating problem of hair loss.

Introducing BURGEON-UP.

BURGEON-UP: A New Mechanism of Action

BURGEON-UP is an extract of Nasturtium Officinale (watercress) that contains the active component 2-O-Feruloyl-L-Malic Acid. The interesting part is that, only the watercress plant that is cultivated in the rich soil of Ibaraki Prefecture in Japan is the variety that produces this active component in abundance.

Based on various studies and tests, BURGEON-UP promotes the secretion of RSPO1 in the hair follicle leading to the activation of dense hair growth and treatment of AGA and female pattern baldness as well as greying hair.

BURGEON-UP

• INCI: water, alcohol, Nasturtium Officinale Leaf/Stem Extract
• Active component: 2-O-Feruloyl-L-Malic Acid
• Recommended dosage: 2%

For more information on this novel hair grower active, email us at info@actichem.com.ph.