Actichem

Cosmetic Active Ingredients

JuniperBright: The True Skin Brightening for Borderless Beauty

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JuniperBright reduces lipofuscin deposit and prevents new formation by dual mechanism of action: proteasome and autophagy.

What is lipofuscin?

Lipofuscin is a yellow-brown pigment that accumulates in cells as part of the normal aging process. It is thought to be a byproduct of oxidative metabolism. It’s often called the “age pigment” or “wear-and-tear pigment” and is a hallmark of aging. Simply put, lipofuscin is the obstacle to skin brightness and radiance and makes the skin dull and look ifeless.

Achieving Skin Clarity and Brightness

The more there is internal reflected light from the skin, the brighter and more attractive the skin appears. To achieve this, the formation of lipofuscin must be prevented and the lipofuscin deposits that have accumulated must be removed or reduced.

Dual Mechanisms to Reduce Lipofuscin: Two Cleaning Systems

1. Ubiquitin-Proteasome System:

The ubiquitin-proteasome system (UPS) is a cellular recycling plant that removes worn-out or unwanted proteins. It works by tagging these proteins with a small protein called ubiquitin, which signals them for destruction by a large protein complex called the proteasome. This process prevents lipofuscin formation.

2. Autophagy

Autophagy is a cellular process that clears cellular waste and damaged components. By removing damaged proteins and organelles like lipofuscin, autophagy contributes to keratinocyte differentiation including regulating pigmentation, maintaining skin barrier and overall skin health and function.

JuniperBright Efficacy Tests

In vitro tests showed 180% increase in proteasome activity in just 2 hours and 115% increase in autophagy activity in less than 8 hours with the addition of 1% Juniperright. Another test showed 60% reduction in lipofuscin accumulation with 0.5% JuniperBright.

In vivo tests showed 10% increase of internal reflected light by TransluDerm measurement with 1% JuniperBright. Since the efficacy is concentration-dependent, it is expected that a 50% increase in internal reflected light can be achieved at 5% concentration for a brighter, more radiant skin.

In vivo tests on the reduction of dark spots showed 15% decrease in the number of spots in 30 days with 1% JuniperBright.

JuniperBright

  • INCI: butylene glycol, water, Juniperus Communis Fruit Extract
  • Description: colorless to brown liquid with characteristic odor
  • Recommended dosage: 1-5%

For more information on this active ingredient, please email us at info@actichem.com.ph.












Acnebusters

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Acnebusters has been around for over a decade but its popularity hasn’t waned through the years. In fact, it continues to gain momentum, that’s because Acnebusters is truly effective in preventing and fighting acne. It’s as simple as that.

But its research and development and its multi-activity is far from simple. In fact, Acnebusters is a complex of 8 botanical actives, each playing a role in the fight against acne, acknowledging the fact that it’s not a straightforward process. It is because of this that Acnebusters has been developed, addressing each phase of the problem of acne.

For an all-encompassing treatment of acne, Acnebusters is the answer:

  • Flavosterone SB and JIOU Liquid B for anti-sebacious gland activity
  • Fermentage PEAR B and Dermaveil to slough off dead skin cells
  • OUBAKU Liquid B to fight against bacteria
  • NEEM Leaf, DOKUDAMI, and OUGON to reduce inflammation and inhibit oxidation

For more information on this product, contact us.

Finding Precious Gem in Arginine!

by Filed Under: Hair, Skin Leave a Comment

From amino acids to peptides to proteins – ACTICHEM got you covered.

Who would have thought that this unassuming amino acid has all the benefits both for skin and hair? To understand what I’m prattling about, read on.

Arginine is a semi-essential amino acid with numerous skin and hair benefits, boasting of these physiological functions:

  • Nitric Oxide (NO) production
  • Immune function
  • Hormone regulation
  • Wound healing and tissue repair
  • Detoxification

So, let’s go on ahead and enumerate the wonders of Arginine:

SKIN BENEFITS:

  • Hydration – assists in the generation of natural moisturizing ingredients; reduces dryness; promotes softer, smoother, more supple skin by drawing water to the skin surface and sealing it in.
  • Skin barrier fortification – promotes ceramides synthesis; reduces trans-epidermal water loss.
  • Collagen production – being an amino acid, Arginine is a building block of protein, which collagen is one, the main extracellular matrix (ECM) protein. Arginine is a requirement for the production of collagen in the skin.
  • Anti-aging activity – by promoting collagen production, it reduces fine lines, wrinkles, loss of elasticity, and skin sagging. Protects skin from oxidative stress which causes cell damage. Improves circulation which brings essential nutrients and oxygen to the skin, promoting skin healing and renewal.
  • Wound healing – Arginine is an active participant in various stages of tissue repair and regeneration
  • Cell proliferation and tissue regeneration – stimulates growth of endothelial and fibroblast cells. Fibroblasts generate collagen and other ECM components.
  • Anti-inflammatory
  • Production of Nitric Oxide – precursor to NO formation. Nitric Oxide aids in wound healing, control of blood flow, stimulation of vasodilation, improvement of tissue repair, cell migration and signaling.
  • Antioxidant properties – eliminates free radicals

***

HAIR AND SCALP CARE:

  • Promotes hair growth – supports the production of Nitric Oxide (NO). NO dilates blood vessels and improves circulation.
  • Strengthens hair
  • Hair regenerative properties – repairs damaged hair; stimulates keratin production
  • Maintains scalp health – improves blood flow to scalp; helps alleviate dandruff, itchiness, dermatitis.
  • Reduces hair loss – strengthens hair shaft and anchors it more securely in the follicle.

Applications:

  • Anti-aging products: anti-wrinkle, lifting, firming, contouring serums, creams, lotions
  • Hair grower serums, shampoo, conditioner
  • Leave-in conditioner, hair mask, gel, cream

Our Product:

SpecKare ARG 100% pure

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***Reference: clinikally.com

SpecPed NIP Max (“Botox-in-a-jar”)

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  • INCI: Dipeptide Diaminobutyroyl Benzylamide Diacetate, S-Mu-Conotoxin CniiiC, Acetyl Hexapeptide-8
  • Activity: Anti-aging, anti-wrinkle, firming, lifting, Botox-like Activity, “Botox-in-a-jar”
  • Applications: anti-aging, firming, and repairing creams, serums, oils, masks, toners
  • Recommended dosage: 0.5-10%

SpecPed NIP Max is a bioactive peptide complex incorporating two powerful neurotransmitter-inhibitory peptides, namely, Acetyl Hexapeptide-8 (SC-AH8) and Mu-Conotoxin CniiiC (SpecPed MCC21).

Mu-Conotoxin CniiiC is a 22-amino acid peptide molecule that belongs to the “Botox-in-a-jar” type of muscle relaxers. That is, it imparts Botox-like effect without the side effects of Botox. Mu-Conotoxin CniiiC is a biomimetic peptide, meaning, it copies the behavior of the natural peptide found in the venomous marine cone snail called Conus Consors. Mu-Conotoxin CniiiC (SpecPed MCC21) is obtained through Biomimetic Molecular Design using Arginine/Lysine Polypeptide.

Acting as topical Botox, SpecPed NIP Max suppresses dynamic fine lines, expression lines and wrinkles. It promotes collagen and elastin syntheses in the dermis, hence, it enhances skin elasticity and firming.

For more information on this product, please contact us.

PromaCare BKL (Bakuchiol)

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  • INCI: Bakuchiol; Phyto Retinol
  • Activity: anti-aging, anti-wrinkle, cell turnover, depigmenting, antioxidant, wound healing, skin regenerating; Retinol-like activity
  • Applications: anti-aging creams and serums

Bakuchiol is a meroterpene phenol abundant in the seeds and leaves of Psoralea Corylifolia. It is the plant-derived, functional analogue of Retinol. Studies show that Bakuchiol upregulates Types I and IV collagen and stimulates Type III collagen as well as Fibronectin protein levels in mature fibroblast model. It also inhibits hyaluronidase, the enzyme that breaks down Hyaluronic Acid, and elastase, the enzyme that breaks down elastin, both of which are vital components of the extracellular matrix.

Compared to Retinol, Bakuchiol has a remarkably strong antioxidation activity. Tests showed Bakuchiol also exhibits powerful wound-healing and skin-regenerating activity faster than Retinol. Bakuchiol has been hailed for its multidirectional efficacy against cellular hallmarks of skin aging.

PromaCare BKL has >99% purity and light honey in color.

For more information on this product, please contact us.

SpecPed GHK-Cu (Copper Tripeptide-1)

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  • INCI: Copper Tripeptide-1
  • Activity: anti-aging, anti-wrinkle, skin-repairing
  • Applications: anti-aging creams and serums

The Copper Tripeptide has been the rage in the cosmetic world for the past few years and thanks to SC Group and Actichem, Cosmetic Peptides are now in the Philippines.

Copper Tripeptide is both a signal peptide and a carrier peptide. As a signal peptide, it triggers wound-healing or skin-regenerating mechanisms that activate fibroblasts in response to fragmented chains of collagen and elastin. In simple terms, there will be more collagen production making the dermal structure stronger and sturdier and the skin firmer.

As a carrier peptide, it delivers copper into the skin, resulting in enzymatic, skin-regenerating pathways to enhance collagen synthesis to answer the problems of lines, wrinkles, and sagging due to age as well as external factors such as UV damage.

Copper Tripeptide-1 is a blue powder in its purest form but Spec-Chem offers it in solutions for easier handling and usage. Available in Actichem are the ff.:

  • SpecPed GHK-Cu 0.1% solution; recommended dosage: 5.0-10%
  • SpecPed GHK-Cu 1.0% solution; recommended dosage: 0.5-5.0%

For more information on this product, please contact us.

SpecPed SC-AH8 (Acetyl Hexapeptide-8)

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  • INCI: Acetyl Hexapeptide-8
  • Activity: neurotransmitter-inhibitory peptide; Botox-like wrinkle-removing activity; anti-aging, anti-wrinkle; safe, non-invasive alternative to Botox; skin firming, lifting
  • Applications: anti-aging creams and serums

Acetyl Hexapeptide-8 as an effective and safe alternative to Botox has a Botox-like wrinkle removing effect by blocking muscle contraction and removing muscle tension. It boosts the expression of extracellular matrix components to improve skin’s elasticity and firmness. Helps promote collagen synthesis to firm up sagging skin and smooth out static and dynamic lines and wrinkles. Being a peptide, it has excellent skin compatibility. Unlike Botox though, it is safe and non-invasive.

It can be combined with other anti-aging actives, like Copper Tripeptide, bioactive microalgae, and/or Bakuchiol to create multidirectional, high-performance products.

SpecPed SC-AH8 comes both in powder and solution forms.

For more info on this product, please contact us.

NT Marine CellShield AP

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  • INCI: Pavlova Lutheri Extract, Capric/Caprylic Triglyceride
  • Activity: protects from urban and indoor pollution, stimulates cell proliferation under stress condition, increases collagen synthesis, lightens skin tone, improves skin homogeneity
  • Applications: protective day creams and sunscreens, after-sun products, night repair creams and serums

Rich in Omega 3 long chain EPA and DHA as well as antioxidants and carotenoids , CellShield AP provides protective barrier for skin, fights inflammation, and protects skin against oxidative stress. Its unique properties provide protection and defense against urban and indoor pollution and environmental stress. Targeted action is against mitochondrial stress thereby increasing cell proliferation.

CellShield AP is a unique natural shield for the skin increasing cell viability and improving skin health conditions. Suitable to use in protective day creams and sunscreens, after sun, and night repair creams and serums.

For more info on this product, please contact us.

NT Marine BlueRev 50+

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  • INCI: Cylindrotheca Fusiformis Extract, Nannochloropsis Oceanica Extract, Triolein
  • Activity: anti-aging, anti-wrinkle, skin densifier, collagen booster, skin elasticity enhancer, moisturizer
  • Naturality: 100% Natural Origin Ingredient
  • COSMOS Certified
  • Applications: anti-aging creams and serums

Thanks to Natura-Tec, the 50+ age group – women who have gained wisdom, grace, and inevitably, signs of aging – is not forgotten. They are the ones who need particular attention, meticulously formulated skincare products that will address problems of fine lines and wrinkles, loss of skin elasticity and radiance, and hyperpigmentation, gathered through the years, both through intrinsic (natural) as well as extrinsic (external factors such as photo damage) aging.

BlueRev 50+ effectively addresses all that as it is a powerful cocktail of bioactive microalgae. It firms up mature skin, increases skin elasticity, densifies and smoothes out mature skin, and provides deep and immediate moisturization. On top of all that, it reduces wrinkles visibility revealing the natural glowing beauty of maturity.

The active components of BlueRev 50+, namely, cholesterol, beta-sitosterol, tocopherols, EPA, and ETA, accelerate skin barrier recovery, improve skin elasticity, promote hyaluronic acid biosynthesis in fibroblasts, protect from UV damage, and increase collagen and elastin fibers expression. Overall, BlueRev 50+ prevents premature aging as well as reverses the signs of aging.

For more info on this product, please contact us.

NT Marine Blue Vital C

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  • INCI: Cylindrotheca Fusiformis Extract (and) Capric/Caprylic Triglyceride
  • Activity: anti-aging, anti-wrinkle; skin firming; lip plumping
  • Applications: anti-aging creams and serums; lip plumping balm, eye cream

NT Marine BlueVital C strongly stimulates collagen synthesis and elastic fibers expression. It provides plumping effect while reducing wrinkles volume and depth. Rich in Eicosapentaenoic Acid (EPA) and Eicosatetraenoic Acid, it regulates dermal fibroblasts activities in wound healing and skin regenerating of connective tissues reorganization. As a result, skin elasticity is improved, making skin firm and supple. In addition, the carotenoids content protects the skin from oxidative stress while sterols stabilize cell membrane.

Highly effective in reversing signs of aging in mature skin, it is recommended for anti-aging, night repair creams and serums. It is also perfect to use in lip plumping products as well as eye contour creams.

For more information on this product and prototype formulations, please contact us.

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