Bio PGA solution is a high-performance cosmetic moisturizer that's produced with fermentation. First, we begin with natto. Natto is a quintessential Japanese delicacy made from fermented soybeans. Natto is very sticky and slimy, imparting a unique and exceptional texture and sensorial experience on the skin. This sticky and slimy component is a high-molecule amino acid called ♈︎-Polyglutamic Acid (PGA). ♈︎-PGA is highly valued in cosmetics, but its production from natto using soybeans is a very expensive process.

Ichimaru Pharcos' solution was to produce ♈︎-polyglutamic acid by fermenting α-polyglutamic acid using Bacillus subtillis var. natto. Due to the bacterial fermentation process, naturally occurring ♈︎-PGA tends to be larger (often 10 to 10,000 kDa) compared to synthetically produced α-PGA.
γ-PGA is the primary form used in premium skin and hair care products because its larger size creates a weightless, breathable, and deeply hydrating film on the skin.
SKIN AND HAIR BENEFITS OF BIO-PGA SOLUTION
- Deep and long-lasting moisturization
- 175% increase in skin hydration for up to 12 hours after just one use with a product containing 1.5% Bio-PGA Solution
- Production of natural moisturizing factor (NMF) increased
2. Barrier improvement
- TEWL was significantly decreased and improvement lasted up to 12 hours in just 1 use
- In 2 weeks, TEWL was down regulated significantly
- Filaggrin production in epidermal cells increased
3. Skin Texture Improvement
- Skin texture and anisotropy were improved in 2 weeks using a product cont. 1.5% Bio-PGA Solution

4. Improvement in skin brightness
- Skin brightness and clarity were improved in just 2 weeks
5. Improvement in makeup application
- Adherence and finishing condition of foundation were improved after using a toner containing 1.5$% Bio-PGA Solution for 2 weeks

6. Hair-smoothing Effects
- Frictional stress of damaged hairs was decreased after just 1 use
7. Stronger Hair
- Tensile strength of damaged hairs was improved after just 1 use

Bio-PGA Solution not only keeps water on the surface of the skin with hydrophilic film but also produces natural moisturizing factor (NMF) as well as it increases filaggrin production.
Applications:
- Moisturizing toners, serums, creams, and lotions
- Facial mist spray
- Day creams and tinted sunscreens
- Shampoos and conditioners
- Hair masks, leave-on conditioners
- Lip balms
For more information on this ingredient, please contact us.
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