Bio-PGA Solution Series (♈︎-Polyglutamic Acid)

by rrperu | Jul 7, 2026 | Hair, homepage, Skin | 0 comments

Bio PGA solution is a high-performance cosmetic moisturizer that's produced with fermentation. First, we begin with natto. Natto is a quintessential Japanese delicacy made from fermented soybeans. Natto is very sticky and slimy, imparting a unique and exceptional texture and sensorial experience on the skin. This sticky and slimy component is a high-molecule amino acid called ♈︎-Polyglutamic Acid (PGA). ♈︎-PGA is highly valued in cosmetics, but its production from natto using soybeans is a very expensive process.

Ichimaru Pharcos' solution was to produce ♈︎-polyglutamic acid by fermenting α-polyglutamic acid using Bacillus subtillis var. natto. Due to the bacterial fermentation process, naturally occurring ♈︎-PGA tends to be larger (often 10 to 10,000 kDa) compared to synthetically produced α-PGA.

γ-PGA is the primary form used in premium skin and hair care products because its larger size creates a weightless, breathable, and deeply hydrating film on the skin.

SKIN AND HAIR BENEFITS OF BIO-PGA SOLUTION

  1. Deep and long-lasting moisturization
  • 175% increase in skin hydration for up to 12 hours after just one use with a product containing 1.5% Bio-PGA Solution
  • Production of natural moisturizing factor (NMF) increased

2. Barrier improvement

  • TEWL was significantly decreased and improvement lasted up to 12 hours in just 1 use
  • In 2 weeks, TEWL was down regulated significantly
  • Filaggrin production in epidermal cells increased

3. Skin Texture Improvement

  • Skin texture and anisotropy were improved in 2 weeks using a product cont. 1.5% Bio-PGA Solution

4. Improvement in skin brightness

  • Skin brightness and clarity were improved in just 2 weeks

5. Improvement in makeup application

  • Adherence and finishing condition of foundation were improved after using a toner containing 1.5$% Bio-PGA Solution for 2 weeks

6. Hair-smoothing Effects

  • Frictional stress of damaged hairs was decreased after just 1 use

7. Stronger Hair

  • Tensile strength of damaged hairs was improved after just 1 use

Bio-PGA Solution not only keeps water on the surface of the skin with hydrophilic film but also produces natural moisturizing factor (NMF) as well as it increases filaggrin production.

Applications:

  • Moisturizing toners, serums, creams, and lotions
  • Facial mist spray
  • Day creams and tinted sunscreens
  • Shampoos and conditioners
  • Hair masks, leave-on conditioners
  • Lip balms

For more information on this ingredient, please contact us.

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