Cureberry is an extract of bilberry leaf from Ichimaru Pharcos, Japan.
Background:
GABA (Gamma Amino Butyric Acid) exists in large amounts in the brain of mammals including humans. In the body, GABA is produced from Glutamic Acid by the action of Glutamic Acid Decarboxylase  or GAD. Ichimaru Pharcos reported for the first time that GAD67, a GABA synthesizing enzyme, exists in the dermal fibroblasts. These findings suggest that GABA is also being produced in the skin.
Furthermore, it was found that GABA enhanced fibroblast functions such as production of hyaluronic acid and biological anti-oxidant glutathione as well as cell growth. However, other studies of the company revealed that the amount of the enzyme GAD67 decreases as the skin ages. It is expected that the decrease in GABA production due to reduction of GAD67 is one of the causes of age-dependent decrease of stress resistance in the skin.
In the study, bilberry leaf extract has been found to increase GAD67 in dermal fibroblasts. Thus, Cureberry, an extract from the bilberry leaf, was developed. Cureberry is a functional cosmetic active ingredient that finds wide use in skin care applications.
- Promotes dermal fibroblast proliferation.
- Promotes Hyaluronic Acid production.
- Promotes Glutathione production.
- SOD-like activity (antioxidant activity)
- Inhibitory effect on collagenase activity (protects skin collagen)
- Inhibitory effect on elastase activity (protects skin elastin)
- Inhibitory effect on histamine release (anti-inflammatory activity)
- Inhibitory effect on B16 melanoma cell (skin whitening activity)
- Inhibitory effect on lipase activity (antioxidant activity)