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Cosmetic Active Ingredients

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Ichimaru’s Visit

July 5, 2016 by rrperu Filed Under: News/Blog Leave a Comment

Last June 19 and 20, the Sales and Marketing staff of Ichimaru, Ryo (pronounced Rio) Nishimaya, a new sales guy, and Takeshi Tsukawaki, visited Manila to introduce Ichimaru’s latest offerings, especially the new active, Izayoi. By the way, Ryo, a half-bred Japanese, is a B.S. ChE graduate from University of the Philippines – Los Baños, Laguna.

The new product, IZAYOI, an extract of the fruit of Rosa Roxburghii plant, was launched at In-Cosmetics, Paris on April 12-14, 2016. It works as a daily UV protection and helps prevent the formation of fine lines and wrinkles and the loss of skin elasticity. For more details and request for product presentation, please contact Actichem or the technical representative assigned to you.

IZAYOI_LEAFLET_04152016-page-001

HIGHLIGHTS OF VISIT:

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Our visitors from Ichimaru with Actichem staff. From left to right: Mr. Ryo Nishiyama, Kate, Jenneth, Karen, Mr. Felix Peru, and Mr. Takeshi Tsukuwaki.

2016-06-20 16.42.33

A visit to Cherard. Takeshi presenting and discussing to Richelle the latest products, Izayoi and soapnut.

2016-06-21 11.08.04

Here at Nutramedica, Takeshi discusses to Ms. malu and Mr. Rene the benefits of Flavosterone. He also presented the efficacy of Ninjin Extract for anti-hair loss.

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At Marklene. Presentation and discussion of some of Ichimaru’s active ingredients, such as Mandarinclear, Cinderellacare, etc.

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Soapnut presentation to Brand Concept’s Mr. Jay Layug and Ms. Annie Soberano.

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Dinner at Gerry’s Grill, Eastwood.

Thank you! ‘Til next.

Proteoglycan-IPC

March 29, 2016 by rrperu Filed Under: Skin Leave a Comment

Proteoglycan-IPC is a solution of proteoglycan extracted from nasal cartilage of salmon, a product of Ichimaru Pharcos, Japan. Proteoglycans are glycoproteins that have a core protein with one or more covalently attached glycosaminoglycan (GAG) chains such as chondroitin sulcate and dermatan sulfate. Proteoglycans are widely distributed in human body parts including skin as a major component of extracellular matrix together with hyaluronic acid and collagen. It has a molecular weight of about 450,000.

proteoglycan

A method to extract a large amount of high-purity proteoglycan from salmon nasal cartilage was established through a joint research project with Hirosaki University, Department of Biochemistry and Kakuhiro Corporation. Eighty pieces of salmon produce 1 kilogram of Proteoglycan-IPC.

Background:

Epidermal Growth factor (EGF) plays an important role in the regulation of cell growth. EGF decreases with aging, causing slower metabolism and the decline of cell regenerative capability.

Ichimaru Pharcos of Japan conducted a study wherein human fibroblasts were cultivated in the presence of 0.1% salmon nasal cartilage-derived proteoglycan (Proteoglycan-IPC) and hyaluronic acid content was examined. The result clarified that Proteoglycan-IPC increases the accumulation of hyaluronic acid in human fibroblasts. EGF has been reported to promote the synthesis and deposition of hyaluronic acid in fibroblasts.

Activity of Proteoglycan-IPC:

Several tests were made to establish the activity and efficacy of Proteoglycan-IPC.

  • EGF-like activity
  • Promotion of Hyaluronic Acid production
  • Promotion of Collagen type 1 production
  • Improvement of rough skin
  • Wrinkle reduction
  • Improvement of skin elasticity
  • Moisturizing effect
  • Whitening effect

Application:

  • Skin care: anti-aging creams, serums, gels, and lotions; moisturizing creams, gels, and lotions

Japanese Brands with Proteoglycan-IPC:

DHC Quick Film Smoother

DHCTarget: anti-aging gel cream

Claim: Proteoglycan is more effective than hyaluronic acid.

Dr. Ci Lab. Super Moisture Gel

Dr. Ci LabTarget: anti-aging/moisturzing gel

Claim: Proteoglycan’s efficacy is the same as EGF and support for skin reborn.

Saisyunkan Cream

SaisyunkanTarget: Super anti-aging cream

Claim: Cream 20 incorporates a “very precious ingredient” – Proteoglycan.

CurePassion

March 8, 2016 by rrperu Filed Under: Skin Leave a Comment

CurePassion is an extract of passionfruit (Passiflora Edulis). The plant is cultivated in Japan in the regions of Okinawa, Kagoshima, Kumamoto, Amami, and Ogasawara. CurePassion was developed by Ichimaru for skin care, particularly, for the care of the lymphatic vessels in the dermal layer of the skin.

passionfruit

Background:

Lymphatic capillary extends to the dermal layer of the skin. It functions as drainage for wastes, toxins, and excess water. Photoaging degrades lymphatic vessels resulting to decreased endothelial cell adhesion. (Endothelial cell is a thin layer of flat epithelial cells that lines serous cavities, lymph vessels, and blood vessels. Epithelial cells are membranous tissues composed of one or more layers of cells). Due to decreased endothelial cell adhesion, lymph fluid leaks out causing fluid retention. This is manifested in the skin as puffiness, dullness, and visible wrinkles.

A fully functioning lymphatic system is important in keeping a healthy and firm skin. Lymphatic endothelial cell growth and lymphatic endothelial cell lumen formation are vital in the formation of new lymphatic vessels.

A fully functioning lymphatic system is important in keeping a healthy and firm skin.

In vitro tests showed that CurePassion increased the growth of lymphatic endothelial cells dose-dependently, as well as lymphatic endothelial cell lumen formation.

Activity:

  • CurePassion increases lymphatic endothelial cell growth
  • CurePassion increases lymphatic endothelial cell lumen formation
  • CurePassion improves dull skin tone (promotes skin brightness)
  • CurePassion improves epidermal barrier function and skin moisturization
  • CurePassion helps reduce wrinkles
  • CurePassion helps minimize dark circles under the eyes and eye bags
  • CurePassion helps reduce facial puffiness and promotes skin firmness
  • CurePassion helps promote healthy skin

Application:

  • Skin care: facial creams, lotions, toners, eye creams
 (All definitions from thefreedictionary.com).

Actichem Welcomes Dr. Arunasiri Iddamalgoda

March 8, 2016 by rrperu Filed Under: News/Blog Leave a Comment

Dr. Arunasiri Iddamalgoda, Director of Research and Development of Ichimaru, Japan, together with Mr. Takeshi Tsukuwaki, sales representative to the Philippines, came to Manila for a 2-day visit. It was the first for Dr. Arunasiri and Actichem was delighted to welcome them. It was rather unusual for a February visit but they wanted to honor Actichem for being no. 1 in sales in 2015.

The first leg of their itinerary was a visit to IRRI (International Rice Research Institute) in UP Los Banos, Laguna. It was a personal visit by Dr. Arunasiri to his friend who is the head of IRRI. Later in the evening, together with Actichem staff, they met up with Dr. Alvin Matulac of ARM Skin for a dinner meeting. New project developments and actives were discussed extensively. It was rather a productive evening.

On their second and last day, they visited Splash, Brand Concept, Skin Perfect and KMI Cosmetics. Dr. Arunasiri presented PrincessCare (geranium extract), Neem Leaf, Clair Blanche II, CurePassion (passionfruit extract), Acne Busters, and other active ingredients that the clients wanted to discuss with him.

Highlights of the visit:

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Dinner meeting with Dr. Alvin Matulac at Sambokojin Restaurant in Quezon City. His new pet projects were discussed with Dr. Arunasiri, most of them using Ichimaru’s latest active ingredients.

 

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Product presentation at Splash by Dr. Arunasiri with Mr. Ronald Mas, Ms. April Llagas, and Ms. Analyn De Asis.

 

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At Brand Concept. Discussion with Mr. Jay Jazul and Ms. Annie Soberano.

 

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Roundtable discussion at KMI with Ms. Sheryl Padrinao, Ms. Marilyn Sengco, and Ms. Lady.

 

20160223_164600

Courtesy call at Skin Perfect. Dr. Arunasiri discussed PrincessCare, BioBenefitty, and Proteoglycan F. Present were Skin Perfect owners Mr. Pierre Ching and Ms. Sheila Ching with Ms. Emy Fernandez.

It was an honor to welcome to our country the R&D Head of our no. 1 supplier Ichimaru Pharcos, Japan. The clients that were visited by Dr. Arunasiri benefited much from the detailed discussions and questions were answered to the satisfaction of both owners and their R&D staff.

‘Til next time!

Kojic Acid Dipalmitate

December 8, 2015 by rrperu Filed Under: Skin Leave a Comment

Kojic Acid has been around for many years as an effective skin whitening agent. It effectively inhibits tyrosinase activity in the process of melanogenesis to help reduce the production of melanin. But there have been problems with the use of Kojic Acid. Because it has the tendency to chelate metal ions, its color easily changes. Also, since it is not strongly stable to light and heat, it oxidizes overtime.

kojic_acid_dipalmitate

But we have good news! Actichem introduces Kojic Acid Dipalmitate. Kojic Acid Dipalmitate is stable to  light and heat and a wide pH range (4-9), thus, providing flexibility to formulators. Since it does not form complexes with metal ions, it is also stable against oxidation and color changes. Because of these improvements, Kojic Acid Dipalmitate is expected to perform far better than its predecessor Kojic Acid.

Recommended dosage: 0.5-3%

 

Phyto Collage (N)

October 26, 2015 by rrperu Filed Under: Hair, Skin Leave a Comment

Phyto Collage (N) is a colorless aqueous, plant-based solution with a high viscosity extracted from fermented soybeans, a product of Ichimaru Pharcos, Japan.

soybeans

Background:

For years, collagen has been used as a raw material for various kinds of cosmetic products. With its effective moisturization and skin protection activities, moderate viscosity, and close affinity to the skin, collagen is greatly beneficial to skin, especially in helping slow down aging.

But the collagen that is of animal origin has also its own disadvantages when it comes to heat stability, pH stability, and compatibility with other raw materials. Furthermore, there is a trend toward avoidance of raw materials of animal origin in accordance with animal protection laws in Europe and the United States. On top of it all, there has been recent problems with livestock, such as cattle, possessing FMD (foot-and-mouth disease).

Phyto Collage (N) was developed to offer a good alternative for animal collagen. A colorless aqueous solution with a high viscosity, Phyto Collage (N) is prepared by purifying high molecular weight materials, the main constituent of which is glutamic acid extracted from fermented soybeans.

Characteristics:

  • Good Moisturization Effect

Determination of TEWL (trans-epidermal water loss) in the skin’s horny layer showed that Phyto Collage (N) has similar moisturization effect with that of animal origin. Phyto Collage (N) promotes the production of Pyrrolidone Carboxylic Acid (PCA) which is one of the components of natural mositurizing factor or NMF.

  • Excellent Skin After-feel: Phyto Collage (N) imparts smoothness to skin without tackiness.
  • Stability:

Phyto Collage (N) has more superior thermal and pH stabilities than animal collagen. It has also good compatibility with other ingredients in formulations.

Applications:

  • Skin Care: anti-aging and sun-protection creams and lotions, eye creams
  • Hair Care: shampoos, conditioners, hair tonics and creams, leave-on conditioners

Joint Japanese Technical Seminar 2015

October 16, 2015 by rrperu Filed Under: News/Blog Leave a Comment

We did it again! Actichem, Ichimaru, and Ajinomoto held their 3rd joint technical seminar on “Japanese Cosmetic Ingredients and Trends for Skin and Hair” last September 29 at Eastwood Richmonde Hotel. The whole-day affair was attended by a slew of company owners, executives, and R & D people from around the Cosmetics Industry.

20150929_113528

Ichimaru was represented by Mr. Norihisa Kawai from R&D Division and Marketing and Advertising Department; Dr. Kazal Boron Biswas,  R&D Division Manager responsible for developing ingredients for anti-aging and skin whitening; Mr. Yuji Usui, Marketing Manager for Asian Market specifically China and Taiwan; and Mr. Takeshi Tsukuwaki, Marketing Manager for Korean and ASEAN market. Ms. Ooi Sok Koon, the indefatigable Product Manager of Ajinomoto’s Specialty Chemicals Division who is responsible for providing technical support in personal care for South East Asia, Australia, China, and India customers represented Ajinomoto, Inc. as usual, joined by Ms. Stephanie Ng, Sales and Marketing Executive for the Specialty Chemicals Division. 

New active and functional ingredients, latest trends and technology, and new and innovative formulations for skin and hair were presented by this roster of seasoned lecturers. Ichimaru unveiled their latest products SkinBaby for sensitive skin care and SkinGuard for pollution care for the first time in the Philippines. Mr. Kawai presented New Clinical Study Data for Clair Blanche II while Mr. Tsukawaki discussed the synergistic effect of CinderellaCare and MandarinClear in formulation for 24-hour beauty and transparent skin.

Among other things, Ms. Sok Koon discussed Facial Cleanser Technology with Amilite GCS-12K and Prodew 500 for hair and scalp care, while Ms. Stephanie Ng presented Hair Shampoo Trends in Japan.

Seminar highlights in photos:

20150929_100515

Mr. Kawai discussing the benefits of their new product SkinBaby.

 

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Launching one of Ichimaru’s latest products, PollutionCare, for the first time in the Philippines.

 

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Dr. Biswas highlights the importance of protecting the skin from pollutants.

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A sumptuous lunch buffet awaited all participants.

 

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Mr. Tsukawaki lecturing on skin whitening and anti-aging technology.

 

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Presentation and lecture on Amisoft ECS-22W by Ms. Sok Koon.

 

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Clients testing sample formulations assisted by Ms. Ng of Ajinomoto-Singapore.

 

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With long-time client-friend Ms. Claire Rivera trying out sample formulations provided by Ajinomoto.

 

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Ajinomoto’s presentation of prestige brands that use their amino-acid based specialty chemicals.

 

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Ichimaru R&D and Foreign Trade, Ajinomoto-Singapore and Manila, and Actichem staff with Mr. Felix Peru.

Doing cosmetics business becomes more exciting with fast-paced active ingredients development and dynamic technical support from our foreign suppliers. Many thanks to Ichimaru and Ajinomoto and to all our valued clients who graced the event and made it successful. More power to you all! ‘Til our next.

CITE Japan 2015

October 9, 2015 by rrperu Filed Under: News/Blog Leave a Comment

In early June, Actichem president, Mr. Felix Peru, travelled to Japan to attend the 7th Cosmetic Ingredients and Technology Expo (CITE) 2015. The bustling, bayside city of Yokohama hosted the once-a-year 3-day event which was attended by a conglomerate of technical people and executives belonging to the Cosmetics Industry from around the world.

At CITE Japan 2015:

2015-06-03 10.06.37

This was Ichimaru Pharcos’ booth. Ichimaru president, Mr. Ando, busy discussing with visitors at the table.

 

2015-06-03 10.07.03

Visitors flocked to Ichimaru Pharcos’ booth, eager to check out their latest cosmetic ingredients offerings.

 

2015-06-03 10.08.00

The event was a great success with more than ten thousand recorded attendees.

 

2015-06-03 16.13.56

View of Yokohama City

Mr. Peru’s itinerary included a trip to Gifu where he visited the headquarters of our major supplier, Ichimaru Pharcos, for the first time. After a whole day of plant visits, he, together with Ichimaru’s marketing staff, then travelled by bullet train to Yokohama.

Gifu Trip Highlights:

DSC_2065

Mr. Felix Peru flanked by Ichimaru’s Foreign Trade staff.

 

briefing

Briefing for all the visitors (other distributors from around Asia like China, who had quite a large delegation) before the plant tour.

 

2015-06-02 14.14.15

Plant tour on-going.

 

2015-06-02 10.06.45

A peek into Ichimaru Pharcos’ laboratories.

 

2015-06-02 09.42.26

A pose beside a cabinet displaying the various international prestigious brands that use Ichimaru’s cosmetic active ingredients.

Ichimaru president, Mr. Ando, wanted to make sure that Mr. Peru experience the “old, traditional Japan”, so he billeted him in a quaint hotel like the one below.

2015-06-02 07.33.37

The facade of Mr. Peru’s hotel in Gifu, Japan.

 

2015-06-01 20.36.02

The traditional Japanese bed where he slept on for a night.

 

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A low table, typical of classic Japanese.

 

2015-06-01 20.41.10

And ceramic tea set.

Alpiniawhite

October 9, 2015 by rrperu Filed Under: Skin Leave a Comment

Alpiniawhite is an extract of the seeds of Alpinia Katsumadai Hayata, a perennial plant which grows abundantly in some parts of China and Taiwan. It is a product of Ichimaru Pharcos of Japan.

alpinia_katsumadai_seeds

Background:

The sun-dried seeds of the Katsumadai plant have been used for medicinal purposes. They contain flavonoids such as alpinetin, cardamonin, and saponin. Recent studies showed that the extract of the Alpnia Katsumadai plant has anti-bacterial, anti-mutagenic, antioxidant, anti-inflammatory, and elastase inhibitory effects.

Efficacy:

In the mechanism of melanogenesis, researchers have recently discovered a new signalling pathway of tyrosinase synthesis, and in the process, finding a unique approach in suppressing melanin production. In this pathway, phospholipid-degrading enzyme (PLD1) plays a prominent role by hydrolyzing phophatidylcholine (PC), the main component of the cell membrane, into phophatidic acid (PA) and choline.

In in vitro tests conducted with B16 melanoma cells, the expression of tyrosinase decreases and intercellular melanin content declines by enhancing PLD1 activity. In this method, it is like putting a brake on the acceleration of tyrosinase, thus, suppressing the process of melanogenesis.

Tests showed that the extract of the seed of Alpinia Katsumadai Hayata, Alpiniawhite, significantly activates the PLD1 pathway resulting in a remarkable skin lightening effect.

Marinwort IPC-11 AGL

October 7, 2015 by rrperu Filed Under: Body, Skin Leave a Comment

Marinwort is a cosmetic ingredient composed of 5 kinds of algae developed to help remove cellulite; a product of Ichimaru Pharcos of Japan.

anti-cellulite

Background:

Accumulation of excessive subcutaneous fat, retention of body fluid, and denaturation of corium are processes that occur in the body forming cellulite. To reduce this excessive accumulation of fat or triacylglycerol, it is necessary to decompose it into fatty acids and glycerol by the action of lipase. The resulting fatty acids are then disposed of in the form of energy. The lipolytic enzyme lipase plays a key role in this process. Lipase is activated in adipose cells through cyclic AMP by the stimulus of some hormones such as adrenaline.

Since lipase is activated through c-AMP, substances that are capable of providing c-AMP externally or inhibit phosphodiesterase which decomposes c-AMP can be used to activate lipase in any specific area of the body.

Marinwort IP-11 AGL has been found to effectively activate lipase. That is, it helps prevent the excessive production of lipid in skin which causes cellulite.

Application:

  • Anti-cellulite products

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